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253 CE - 260 CEReign of Roman emperor Valerian with his son Gallienus as co-emperor.
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253 CE - 268 CEReign of Gallienus in Rome.
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c. 256 CEKing Chrocus of the Alemanni invades Gaul and destroys the region.
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259 CEThe Alemanni invade Italy.
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260 CEShapur I captures the Roman emperor Valerian at Edessa.
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262 CE - 266 CEOdaenathus expels Persian garrisons and restores Syria and Armenia to the Roman Empire. Odaenathus invades Mesopotamia, and inflicts two defeats upon Shapur I, which ends with the sack of Ctesiphon.
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265 CEGallienus builds walls around Verona.
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c. 266 CE - c. 267 CEOdaenthus is assassinated.
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267 CEZenobia rules as Regent in Palmyra.
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268 CEGallienus defeats Aureolus at Mediolanum.