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Jan 329 BCE - May 327 BCEAlexander conquers Bactria and Sogdiana.
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c. Mar 327 BCEAlexander the Great marries the Bactrian girl Roxanne.
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293 BCEAntiochos is appointed vice-king of the Upper-Satrapies by his father Seleucus I Nicator.
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c. 280 BCEIncursion of northern nomads (Sakas) on Seleucid territories.
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250 BCEFormer satrap Diodotos rebels against Seleucid king Antiochos I, creating the Greco-Bactrian kingdom.
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c. 230 BCEDiodotos II is overthrown by Euthydemos. Beginning of the Euthydemid dynasty.
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208 BCE - 206 BCESiege of Bactra by Antiochos III.
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c. 200 BCE - c. 100 BCEScythians tribes migrate into Bactria, Sogdiana and Arachosia.
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c. 180 BCE - 80 BCEPeriod of Indo-Greek rule in the Gandhara region.
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145 BCEMurder of Eucratides by his son. Weakening of the Greco-Bactrian kingdom.
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c. 145 BCEEucratidia is taken by the Sakas.
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c. 139 BCEEucratidia is looted to the ground by the Yuezhei.
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c. 130 BCEThe Yuezhei take control of Bactria.
