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1200 BCEIonian migrations into the region around Ephesos.
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c. 550 BCE - c. 430 BCEConstruction of the Temple of Artemis at Ephesus, one of the Seven Wonders of the Ancient World.
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547 BCEAnatolia conquered by the Persians. Ephesos remains neutral.
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21 Jul 356 BCEThe Temple of Artemis at Ephesus is destroyed by a deliberate fire.
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c. 355 BCE - c. 330 BCEThe Temple of Artemis at Ephesus is rebuilt/restored.
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334 BCEEphesos liberated from Persian rule by Alexander the Great.
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c. 320 BCEEphesos renamed Arsineia by Lysimachus following Alexander the Great's death.
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c. 300 BCE - c. 290 BCETheatre of Ephesos constructed.
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281 BCECity is re-founded as Ephesos.
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129 BCEEphesos becomes part of the Roman Empire.
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88 BCEMithridates Rebellion and massacre of Latin speaking Ephesians by Sulla.
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17 CEEarthquake destroys much of Ephesos.
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c. 60 CE - 130 CELife of the physician Soranus of Ephesos.
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c. 70 CEThe rise of Christianity contributes to the cultural and physical decline of the city of Ephesos.
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114 CEThe Library of Celsus at Ephesos commissioned by Tiberius Julius Acquila.
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117 CEThe Library of Celsus at Ephesos completed.
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c. 138 CETemple dedicated to Hadrian built in Ephesos.
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262 CEThe Library of Celsus at Ephesos destroyed by fire during invasion by the Goths.
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c. 267 CEThe Goths plunder and destroy the Temple of Artemis at Ephesus.
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401 CEThe Temple of Artemis at Ephesus is destroyed by a Christian mob.