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c. 1080The Hospital of Saint John in Jerusalem is established by what would become the Knights Hospitaller.
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1100The Order of Hospitallers of St. Anthony is established in Grenoble, France.
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1113The Knights Hospitaller are recognised as a religious order by Pope Paschal II.
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1113The Blessed Gerard is officially appointed the first master of the Knights Hospitaller.
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1120Raymond du Puy becomes master of the Knights Hospitaller.
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1122The Knights Hospitaller establish a hospital in Utrecht.
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c. 1130The first Rule of the Knights Hospitaller is compiled.
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1135 - 1154The Church grants the Knights Hospitaller order independence from any local religious authority.
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1136The Knights Hospitaller are given the castle of Beth Gibelin, Jerusalem.
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1144The Knights Hospitaller acquire the castle of Krak des Chevaliers in Syria.
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1186The Knights Hospitaller gain control of Marqab (Margat) castle in Syria.
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Jul 1188Saladin besieges the Knights Hospitaller castle of Krak des Chevaliers but withdraws to meet the Third Crusade.
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1191After the fall of Jerusalem the Knights Hospitaller move their base to Acre.
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1202An earthquake damages the castle of Krak des Chevaliers in Syria which is then rebuilt and enlarged by the Knights Hospitaller.
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8 Apr 1271Al-Zahir Baibars, Sultan of Egypt and Syria, captures the Knights Hospitaller castle of Krak des Chevaliers.
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1306The Knights Hospitaller, looking for a new base, attack Byzantine Rhodes.
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1309The Knights Hospitaller establish a new headquarters on Rhodes.
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1397The Knights Hospitaller buy Corinth from the Byzantine Empire.
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1403The Knights Hospitaller lose control of Corinth to the Ottomans.
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1530The Knights Hospitaller establish a new headquarters on Malta.