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1505 - 1961The Estado da India is in existence, that part of the Portuguese Empire from East Africa to Japan.
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1505The Portuguese begin to attack cities and build forts along the Swahili Coast in order to control trade.
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1510 - 1961Goa on the west coast of india is a Portuguese colony.
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1510Afonso de Albuquerque conquers Goa in India for Portugal.
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1511Afonso de Albuquerque captures Malacca in Malaysia for Portugal.
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1511 - 1641Malacca in Malaysia is a Portuguese colony.
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1515Hormuz at the mouth of the Persian Gulf is colonized by the Portuguese.
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1518The Portuguese establish a fort at Colombo, Sri Lanka.
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1519 - 1522Ferdinand Magellan's expedition circumnavigates the globe for the first time.
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1519The Portuguese establish a fort at Kollam in India.
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1521The Portuguese establish a fort at Chaul in India.
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1530Portuguese Goa replaces Cochin as the capital of the Estado da India.
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1533A papal bull establishes the archdiocese of the Estado da India.
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1543Three Portuguese mariners accidentally land in Japan, the first Europeans to do so.
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1546The Portuguese establish a formidable fortress on Mozambique Island.
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c. 1557The Chinese Ming Dynasty grants the Portuguese a trading base of their own at Macao.
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1571 - 1639The Portuguese control the port of Nagasaki in Japan.
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c. 1571The Japanese daimyo Omura Sumitada grants the Portuguese control of Nagasaki.
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1596The Dutch arrive in Southeast Asia and challenge the Portuguese and their empire.
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1604A Council of State is established at Portuguese Goa.
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1622The Persians, with English assistance, take control of Hormuz from the Portuguese.
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c. 1633The Portuguese conquer the southern African kingdom of Mutapa.
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Dec 1637 - Apr 1638The Shimabara Uprising in Japan which the shogunate blames on Christians, leading to an expulsion of all Europeans.
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1638 - 1644Dutch forces attempt to blockade Portuguese Goa.
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1640 - 1668Spain is at war with Portugal.
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1641The Dutch attack and take over Portuguese Malacca.
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1656The Dutch attack and take over Portuguese Colombo.
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1663The Dutch attack and take over Portuguese Cochin.
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1799 - 1815Portuguese Goa is occupied by the British during the Napoleonic Wars.
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1961Portuguese Goa is invaded by the Indian military.
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1999Portuguese Macao is handed over to China.