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The human body's system of blood circulation was discovered by the English physician and anatomist William Harvey (1578-1657) in 1628. Harvey determined the relationship between the blood system of arteries and veins and the regular contractions...

Martin Luther's 95 Theses, credited with sparking the Protestant Reformation in Europe, have become a cultural touchstone since he posted them 31 October 1517, but the little-known 97 Theses, posted only a month earlier, are equally significant...

The sea dogs, as they were disparagingly called by the Spanish authorities, were privateers who, with the consent and sometimes financial support of Elizabeth I of England (r. 1558-1603 CE), attacked and plundered Spanish colonial settlements...

The estimated expanse of the Achaemenid Empire at its height c. 500 BCE was two million square miles. Most of this territory was conquered by Cyrus the Great, the founder of the Empire, who reigned from 559 to 530 BCE, the fourth king in...

The Battle of Megiddo (c. 1457 BCE) is one of the most famous military engagements in history in which Thutmose III (1458-1425 BCE) of Egypt defeated the coalition of subject regions led in rebellion by the kings of Kadesh and Megiddo. The...

Huldrych Zwingli (l. 1484-1531) broke with the Church in 1522 and defended his beliefs at the First Disputation in 1523, encouraging many people in Zürich to embrace his teachings. Among his followers was a group, soon known as Anabaptists...

Hannibal Barca (l. 247-183 BCE), the brilliant Carthaginian general of the Second Punic War (218-202 BCE), had the military talent, expertise, and skill to have won the conflict but was denied the resources by his government. The Carthaginian...

In 36 BCE, Mark Antony (83-30 BCE) invaded Parthia, hoping to render himself one of the great conquerors of the Greco-Roman world, but he was stymied by Parthian forces and obliged to undertake an arduous, costly retreat. What to make of...

The Spanish explorer Hernando de Soto (c. 1500-1542) landed on the west coast of Florida on 30 May 1539, hoping to find wealthy kingdoms to conquer and plunder. His crew journeyed for over four years in southeastern North America, savaging...

The English historian Edward Gibbon (1737-1794) wrote and published his seminal work History of the Decline and Fall of the Roman Empire between 1776 and 1788. The dominant theme of Gibbon's six-volume work is that the fall of the Roman Empire...