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321 BCEThe Via Appia, a famous Roman road, is constructed.
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312 BCERome's first aqueduct constructed, the 16 km long Aqua Appia.
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219 BCEThe physician Archagathus of Sparta arrives in Rome.
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c. 159 BCEFirst water-clock set up in Rome.
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c. 25 BCE - c. 50 CELife of the Roman physician Aulus Cornelius Celsus.
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c. 20 BCEMilitary engineer and architect Vitruvius publishes his "De Architectura".
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c. 20 BCEThe Campus Martius baths in Rome are constructed and donated to the people by Agrippa.
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41 CERoman emperor Claudius builds a 6 km tunnel to drain the Fucine Lake.
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c. 50 CEThe largest Roman aqueduct, 49 m high, completed at Pont du Gard.
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c. 65 CEThe Circus Maximus in Rome is rebuilt and its capacity increased to 250,000.
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81 CE - 96 CEConstruction is finally completed on the Colosseum of Rome in the reign of Domitian.
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122 CEConstruction begins on Hadrian's Wall.
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c. 125 CEThe Pantheon is completed in Rome.
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129 CE - c. 216 CELife of the physician Galen of Pergamon.
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c. 235 CEThe Baths of Caracalla in Rome are completed.