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c. 1345 - 1521The Aztec civilization flourishes in Mesoamerica.
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1418Texcoco is temporarily conquered by Mexica and Tepanec forces.
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1428The Triple Alliance is formed between Tenochtitlan, Texcoco and Tlacopan.
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c. 1450The Aztecs establish a garrison at Mitla in the Oaxaca Valley.
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c. 1485The Stone of Tizoc is carved depicting the Aztec king Tizoc attacking warriors from the Matlatzinca.
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1487The Templo Mayor is completed at Tenochtitlan and inaugurated with the sacrifice of 20,000 captives.
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c. 1494Aztec leader Ahuitzotl conquers the central valleys of Oaxaca.
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c. 1499Aztec leader Ahuitzotl conquers the Soconusco region.
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c. 1507The Throne of Motecuhzoma II is carved. Also known as the Monument of Sacred War.
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1521Texcoco provides ships and men to aide the Spanish siege of Tenochtitlan.
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13 Aug 1521The Aztec capital of Tenochtitlan falls into the hands of Spanish forces led by Hernán Cortés.