Persis passes from Seleucid to Parthian domination.
Marcus Licinius Crassus is made consul for the second time and departs on campaign in Parthia.
Battle of Carrhae. Crassus is captured and executed by the Parthians.
Parthian king Vologases I invades Armenia.
58 CE - 63 CE
Roman emperor Trajan annexes Armenia and declares war on Parthia.
127 CE - 150 CE
The Kushana emperor Kanishka conquers Kashmir, defeats Parthians, reaching the kingdom of Magadha. He crosses the Pamir mountains and defeats the Chinese under General Pan Yang and annexes Kashgar, Khotan and Yarkand.
161 CE - c. 166 CE
Parthian Wars with Rome; Lucius Verus commands Rome's forces in the field.