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c. 700 BCEGreek poet Hesiod writes his Theogony and Works and Days.
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c. 500 BCEAsclepius becomes principal god of worship at Epidaurus.
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400 BCE - 390 BCEA sanctuary to Asclepius is built at Agrigento.
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c. 380 BCE - c. 375 BCETemple to Asclepius constructed at Epidaurus.
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c. 350 BCEThe Ascelpeion is built on Kos.
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c. 340 BCE - c. 330 BCETheatre of Epidaurus first constructed.
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292 BCEThe Romans adopt the Greek god of medicine Asclepius by stealing his sacred snake from Epidaurus and setting up a temple on the Tiber Island.
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242 BCEThe games held in honour of Asclepius on Kos are given Panhellenic status.
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426 CERoman Emperor Theodosius II orders closure of Epidaurus sanctuary.