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c. 437 BCEAthens founds the colony of Amphipolis in northern Macedonia.
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424 BCESpartan general Brasidas takes Amphipolis, Thucydides failed to prevent this and is exiled.
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422 BCEThe Athenians, led by Cleon, try to retake Amphipolis but are defeated by Brasidas.
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422 BCESpartan general Brasidas dies of his wounds at Amphipolis.
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367 BCEAmphipolis makes an alliance with the Chalcidian League.
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364 BCEMacedonian general Perdiccas III successfully defends Amphipolis against Athenian attack.
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168 BCEAmphipolis falls under Roman control.
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500 CEAmphipolis becomes an important Christian centre and has four basilicas.