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c. 1345 - 1521The Aztec civilization flourishes in Mesoamerica.
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1486 - 1502Ahuitzotl reigns as leader of the Aztec Empire.
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1487The Templo Mayor is completed at Tenochtitlan and inaugurated with the sacrifice of 20,000 captives.
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c. 1494Aztec leader Ahuitzotl conquers the central valleys of Oaxaca.
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c. 1499Aztec leader Ahuitzotl conquers the Soconusco region.
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1502 - 1520Motecuhzoma II reigns as leader of the Aztec Empire.