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733 BCE: Corinth founds the colony of Syracuse in Sicily.
491 BCE - 478 BCE: Gelon is tyrant of Syracuse.
480 BCE: Tyrant of Syracuse Gelon defeats the Carthaginians at the battle of Himera.
478 BCE - 467 BCE: Hiero I is tyrant of Syracuse.
474 BCE: An Etruscan fleet is defeated by the navy of Syracuse at the Battle of Cumae.
415 BCE - 413 BCE: Athenian expedition to attack Syracuse.
405 BCE: Dionysius becomes tyrant in Syracuse, Sicily.
398 BCE - 380 BCE: Plato travels in Egypt, Cyrene, Italy, Syracuse and Sicily.
397 BCE: Dionysius I of Syracuse employs wheeled seige towers and bolt throwers for the first time in Greek warfare at the seige of Motya.
384 BCE: Syracuse attacks the ports of the Etruscan city of Cerveteri.
367 BCE: Plato's second trip to Syracuse.
367 BCE: Dionysius II becomes tyrant of Syracuse, Sicily.
361 BCE: Final attempt by Plato to make Syracusan king a philosopher-king.
356 BCE: Dion becomes tyrant of Syracuse.
346 BCE: Dionysius II is once again tyrant of Syracuse.
344 BCE: Timoleon defeats Dionysius II of Syracuse and establishes an oligarchy government.
344 BCE: Corcyra contributes two ships to Timoleon's fleet which attacked Syracuse.
330 BCE: Agathocles is exiled from Syracuse.
319 BCE: Agathocles of Syracuse declares himself strategos auotkrator.
317 BCE: Agathocles takes power in Syracuse.
311 BCE: A Carthaginian army defeats Agathocles of Syracuse near Gela, Sicily.
310 BCE: Agathocles of Syracuse lands an army of 14,000 in North Africa.
309 BCE: Syracuse defeats a Carthaginian army in Sicily and kills their general Hamilcar.
309 BCE - 308 BCE: Agathocles of Syracuse successfuly campaigns in North Africa defeating Carthaginian armies and taking Utica and Hippacra.
307 BCE: Syracusan tyrant Agathocles sacks the city of Segesta.
307 BCE: Carthage defeats the army of Agathocles of Syracuse led by Archagathus while Agathocles is in Sicily.
306 BCE: Agathocles declares himself king of Syracuse.
306 BCE: Carthage and Agathocles of Syracuse sign a peace treaty and divide Sicily between them.
300 BCE: Agathocles of Syracuse campaigns in Italy and captures Bruttium.
295 BCE: Agathocles of Syracuse captures Croton in southern Italy.
289 BCE: Agathocles of Syracuse dies from poison or illness.
288 BCE: Hicetus becomes tyrant of Syracuse.
270 BCE - 215 BCE: Hiero II is tyrant of Syracuse.
214 BCE: Syracuse joins the side of Carthage in the Second Punic War.
213 BCE - 212 BCE: Roman commander Marcus Claudius Marcellus lays seige to and ultimately sacks Syracuse.
211 BCE: Marcus Claudius Marcellus is given a triumph for his capture of Syracuse and victories in Sicily.
201 BCE: Syracuse joins the Roman Republic, province of Sicily is formed.