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321 BCE - 315 BCE: Seleucos rules the satrapy of Babylon.
312 BCE: Seleucos conquers Babylon and founds the Seleucid dynasty.
312 BCE - 63 BCE: Duration of the Seleucid Empire.
312 BCE: Evagros is killed in battle by Seleucos I. Persis comes under Seleucid rule.
305 BCE: Emperor Chandragupta signs a treaty with Seleucos I, establishing borders and giving the Punjab to Chandragupta in return for 500 war elephants.
305 BCE - 281 BCE: Seleucus I Nicator rules newly founded Seleucid Empire.
301 BCE: Battle of Ipsos. Death of Antigonos, rise to power of Lysimachus and Seleucus.
301 BCE - 299 BCE: Antioch founded by Seleucos I Nicator.
281 BCE - 261 BCE: Reign of Antiochus I Soter of the Seleucid Empire.
280 BCE: Lydia becomes a part of the Seleucid Empire.
275 BCE: Seleucids successfully defeat the Galatian Celts in the 'Elephant Battle'.
274 BCE - 271 BCE: The first Syrian war, marking the beginning of the contest between the Ptolemies and the Seleucids for Phoenicia and Coele-Syria.
262 BCE: Eumenes rebels and wins against the Seleucid Antiochus I. Beginning of the Pergamon Empire.
261 BCE: Antiochus I Soter of the Seleucid Empire killed in battle against the Galatians at Ephesus in Asia Minor.
261 BCE - 246 BCE: Reign of Antiochus II Theos of the Seleucid Empire.
250 BCE: Former satrap Diodotos rebels against Seleucid king Antiochos I, creating the Greco-Bactrian kingdom.
246 BCE: Galatians defeat Seleucus II in a battle near Ancyra.
223 BCE - 187 BCE: Reign of Antiochus III the Great who reunites the Seleucid Empire.
210 BCE - 204 BCE: Antiochos III campaigns to reunite Seleucid Empire.
203 BCE: The Seleucid king, Antiochus III Megas signs a treaty with Philip V of Macedon to divide Egypt and its overseas possessions between them.
195 BCE: After the battle at Panion, the Seleucids finally take the rule of Phoenicia from the Ptolemies. Tyre and the other Phoenician cities will remain in the Seleucid power until the Roman conquest of Syria.
195 BCE: Facing the threat of being handed to the Romans after the Second Punic War, Hannibal flees to the Seleucid court of Antiochus III and becomes his advisor.
190 BCE: Battle of Magnesia ad Sipylum, disastrous defeat for Antiochos III against Romans.
188 BCE: The treaty of Apamea Kibotos. Peace and alliance is established between the Seleucid Empire and Rome joined by its allies, such as Pergamon and Rhodes. The Seleucids have to evacuate all the land and the cities from Asia Minor and to pay a huge war indemnity.
175 BCE - 163 BCE: Reign of Antiochus IV Epiphanes of the Seleucid Empire.
141 BCE: Persis passes from Seleucid to Parthian domination.
140 BCE - 138 BCE: Cilician Pirates grow in power under the reign of Diodotus Tryphon of the Seleucid Empire.
83 BCE: Tigranes II invades and destroys the Seleucid Empire.
65 BCE - 63 BCE: Reign of Philip II Philoromaeus, last monarch of the Seleucid Empire. .
63 BCE: The Roman general Pompey defeats the Seleucid Antiochus XIII and incorporates Syria as a province of the Roman empire.