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400 BCE
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100 CE
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321 BCE: The Via Appia, a famous Roman road, is constructed.
312 BCE: Rome's first aqueduct constructed, the 16 km long Aqua Appia.
219 BCE: The physician Archagathus of Sparta arrives in Rome.
159 BCE: First water-clock set up in Rome.
25 BCE - 50 CE: Life of the Roman physician Aulus Cornelius Celsus.
20 BCE: Military engineer and architect Vitruvius publishes his "De Architectura".
20 BCE: The Campus Martius baths in Rome are constructed and donated to the people by Agrippa.
41 CE: Roman emperor Claudius builds a 6 km tunnel to drain the Fucine Lake.
50 CE: The largest Roman aqueduct, 49 m high, completed at Pont du Gard.
65 CE: The Circus Maximus in Rome is rebuilt and its capacity increased to 250,000.
81 CE - 96 CE: Construction is finally completed on the Colosseum of Rome in the reign of Domitian.
122 CE: Construction begins on Hadrian's Wall.
125 CE: The Pantheon is completed in Rome.
129 CE - 216 CE: Life of the physician Galen of Pergamon.
235 CE: The Baths of Caracalla in Rome are completed.