1853 CE - 1856 CE: The Crimean War between Russia and the Ottoman Empire and its allies.

1854 CE: Florence Nightingale brings attention to the poor sanitary conditions in the military hospital at Scutari in the Crimea and lobbies for new facilties to be built.

1855 CE: Isambard Kingdom Brunel is approached by the British government to design a new type of hospital for use in the Crimean War, the Renkioi Hospital.

1855 CE: The first prefabricated ward buildings of the Renkioi Hospital in the Crimea (designed by Isambard Kingdom Brunel), are built.

1855 CE: The prefabiricated Renkioi Hospital is completed in the Crimea. The hospital enjoys an extremely high success rate of rehabilitating patients.