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323 BCE - 282 BCE: Library of Alexandria is proposed and possibly established during the reign of Ptolemy I of Egypt.
323 BCE - 145 BCE: The Library of Alexandria flourishes under the patronage of the early Ptolemaic Dynasty of Egypt.
282 BCE - 246 BCE: Library of Alexandria built during the reign of Ptolemy II of Egypt.
246 BCE - 221 BCE: Collection of the Library of Alexandria expands during the reign of Ptolemy III of Egypt.
145 BCE: The Library of Alexandria loses patronage under the reign of Ptolemy VIII; foreign scholars are expelled from Alexandria.
145 BCE - 48 BCE: Library of Alexandria declines through lack of patronage by Ptolemaic Dynasty of Egypt.
51 BCE - 30 BCE: Library of Alexandria still exists during the reign of Cleopatra VII of Egypt.
48 BCE: Storehouse of the Library of Alexandria near the port is destroyed by fire set by Julius Caesar.
313 CE - 415 CE: Whatever remains of Library of Alexandria declines further with the rise of Christianity in Alexandria, Egypt.