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1450 CE
1460 CE
1470 CE
1480 CE
1490 CE
1500 CE
1451 CE: Isabella I of Castile is born in Madrigal de las Altas Torres, Spain.
1469 CE: Isabella I of Castile and Ferdinand II of Aragon are married.
1474 CE - 1504 CE: Isabella I of Castile's reign over Castile.
1478 CE: Isabella I of Castile and Ferdinand II of Aragon create the Tribunal of Holy Office of Inquisition, or the Spanish Inquisition.
1479 CE: Castile and Aragon are united into one kingdom.
1492 CE: Granada is reconquered from the Muslims through Isabella I of Castile's efforts.
1492 CE: Isabella I of Castile provides Christopher Columbus with monetary support for exploration.
1504 CE: Isabella I of Castile dies in Medina del Campo, Spain.