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550 BCE
540 BCE
530 BCE
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200 BCE
544 BCE: Foundation of Cyropolis on the Iaxartes river.
530 BCE: Cyrus II killed by the Massagetae of Tomyris' army near the Iaxartes.
329 BCE: Alexander the Great wins a decisive battle at the Iaxartes river against the Scythians.
329 BCE: Alexander the Great founds Alexandria-Eschate on the Iaxartes and destroys Cyropolis.
200 BCE: Sakas conquer the Sogdiana part of the Iaxartes.