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1500 CE
1510 CE
1520 CE
1530 CE
1540 CE
1500 CE - 1542 CE: Life of the Spanish conquistador Hernando de Soto.
1514 CE: Hernando de Soto sails for Panama.
1517 CE: Hernando de Soto explores Colombia.
1524 CE: Hernando de Soto joins an expedition led by Francisco Hernández de Córdoba bound for what is today Nicaragua.
1532 CE: Hernando de Soto is a key commander in the army of conquistadors led by Francisco Pizarro which conquers the Inca civilization.
1535 CE: The conquistador Hernando de Soto leaves the Americas and returns to Spain.
1537 CE: Hernando de Soto is made a Knight of Santiago, the governor of Cuba, and awarded the status of adelantado for North American exploration.
1539 CE - 1542 CE: The spanish conquistador Hernando de Soto leads an expedition of discovery and conquest in Florida and the southwestern part North America.
1542 CE: The Spanish conquistador Hernando de Soto dies near Natchez and his body is comitted to the Mississippi River.