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437 BCE: Athens founds the colony of Amphipolis in northern Macedonia.
424 BCE: Spartan general Brasidas takes Amphipolis, Thucydides failed to prevent this and is exiled.
422 BCE: The Athenians, led by Cleon, try to retake Amphipolis but are defeated by Brasidas.
422 BCE: Spartan general Brasidas dies of his wounds at Amphipolis.
367 BCE: Amphipolis makes an alliance with the Chalcidian League.
364 BCE: Macedonian general Perdiccas III successfully defends Amphipolis against Athenian attack.
168 BCE: Amphipolis falls under Roman control.
500 CE: Amphipolis becomes an important Christian centre and has four basilicas.