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357 BCE: Marriage of Olympias to Philip II of Macedonia.
356 BCE - 323 BCE: Life of Alexander the Great.
346 BCE: Alexander tames Bucephalus, his war horse.
343 BCE: King Philip II of Macedon summons Aristotle to tutor his young son Alexander (later 'The Great').
338 BCE: The Battle of Charonea gives Athens to the Macedonian victors. Agora takes on Macedonian characteristics.
336 BCE - 323 BCE: Reign of Alexander the Great.
335 BCE: Alexander the Great receives Celtic ambassadors in the Balkans.
334 BCE: Ephesos liberated from Persian rule by Alexander the Great.
334 BCE - 323 BCE: Campaigns of Alexander the Great.
334 BCE: Sardis surrenders to Alexander the Great.
334 BCE: Alexander invades the Persian empire.
334 BCE - 324 BCE: Antipater is regent of Macedon in Alexander's absence.
333 BCE: Alexander the Great conquers Aleppo.
333 BCE: Battle of Issus. Alexander is victorious against Darius III of Persia.
332 BCE: Alexander the Great sacks Sidon.
332 BCE: Alexander the Great sacks Baalbek and renames it Heliopolis.
332 BCE: Conquest of the Levant by Alexander the Great who destroys Tyre.
332 BCE: Alexander the Great conquers Phoenicia and turns toward Egypt.
332 BCE: Alexander the Great besieges and conquers Tyre.
332 BCE: Alexander the Great visits the Oracle of Ammon at Siwa and is declared "master of the Universe" and son of Ammon.
331 BCE: Egypt is conquered by Alexander the Great without resistance.
331 BCE: Alexander the Great founds Alexandria at the port town of Rhakotis in Egypt.
331 BCE: Susa surrenders without contest to Alexander the Great who sacks it.
331 BCE: Battle of Gaugamela. Alexander calls himself "King of Asia."
330 BCE: Persepolis is burned and looted by Alexander the Great.
329 BCE: Alexander the Great wins a decisive battle at the Iaxartes river against the Scythians.
329 BCE - 327 BCE: Alexander conquers Bactria and Sogdiana.
329 BCE: Alexander the Great founds Alexandria-Eschate on the Iaxartes and destroys Cyropolis.
327 BCE - 326 BCE: Alexander's campaign in northern India.
327 BCE: Alexander the Great marries the Bactrian girl Roxanne.
326 BCE: Battle of Hydaspes where King Porus of the Paurava kingdom met a disastrous defeat at the hands of Alexander the Great.
326 BCE: Death of Bucephalus.
326 BCE: Alexander the Great halts his eastward march and turns back from the banks of the river Beas, Punjab, India.
325 BCE - 320 BCE: Greek rule in Gandhara, ending some time after the death of Alexander the Great.
324 BCE: Alexander the Great orders restoration work in Pasargadae.
324 BCE: Death of Hephaestion.
323 BCE: Alexander the Great receives Celtic delegations in Babylon.
322 BCE - 275 BCE: The Wars of the Diadochi, also known as the Wars of Alexander's Successors.
316 BCE: Death of Olympias, mother of Alexander the Great.
310 BCE: Assassination of Roxanne and Alexander IV, wife and son of Alexander the Great.